Seminar on Qualitative Theory of Differential Equations - Anna Hudertmark (20.3.2025)
Thursday 20.3.2025 at 14:00, Lecture room M 223
Anna Hudertmark (RPTU Kaiserslautern-Landau):
Modeling of carotid artery hemodynamics towards a CFD database for stroke risk assessment
Abstract:
In medicine, the risk assessment of strokes caused by pathological irregularities in the bifurcation of the carotid artery plays a major role in the patient's optimal treatment decision. This decision-making process can be greatly enhanced by detailed flow field data obtained from simulations using patient-specific arterial morphologies. We present our numerical modeling approach to create a CFD database that can guide stroke risk assessment, including hemodynamic shear risk metrics. We investigate the multi-directional behavior of wall shear stress (WSS) based on specially constructed longitudinal tangent vectors using a center-line projection approach and present the utility of longitudinal WSS evaluation for detecting opposing or transverse WSS in slow patient-specific flow. In our fluid-structure interaction model, we generalize the assumption of linear elasticity by a strain-dependent elastic modulus that is consistent with laboratory measurements of compliance and distensibility. Finally, we present the established working pipeline to generate CFD data for a large number of patient-specific geometries. Created hemodynamic datasets can be used for visual atlases and comparative analysis or explored by neural networks.