Seminar on Qualitative Theory of Differential Equations - Christopher Morison (6.11.2025)

Thursday 6.11.2025 at 14:00, Lecture room M 223

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Christopher Morison:
Somatic mutations accumulate stochastically in cancer cell populations

Abstract:
New distributions of mutational information are measurable thanks to single-cell sequencing technology. I first describe how some of these can be derived from a simple branching process model of neutral evolution. Using the neutral model as a baseline against which one can measure selection, I next consider cancer cells acquiring deleterious antigenic mutations, triggering the immune system, which seeks to eliminate them. Informed by stochastic simulations, I finally discuss what coevolutionary dynamics take place under different regimes of interactions between the immune cells and their cancer prey and how this can inform immunotherapeutic treatments.

 

 

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