Fakulta matematiky, fyziky
a informatiky
Univerzita Komenského v Bratislave

Seminár z kvalitatívnej teórie diferenciálnych rovníc - Candan Çelik (7.10.2021)

vo štvrtok 7.10.2021 o 14:00 hod. v miestnosti M/223


30. 09. 2021 14.07 hod.
Od: Pavol Quittner

Prednášajúci: Candan Çelik

Názov prednášky: Protein noise and distribution in a two-stage gene-expression model extended by an mRNA inactivation loop

Termín: 7.10.2021, 14:00 hod., M 223

Abstrakt:
Chemical reaction networks involving molecular species at low copy numbers lead to stochasticity in protein levels in gene expression at the single-cell level. Mathematical modelling of this stochastic phenomenon enables us to elucidate the underlying molecular mechanisms quantitatively. Here we present a two-stage stochastic gene expression model that extends the standard model by an mRNA inactivation loop. The extended model exhibits smaller protein noise than the original two-stage model. Interestingly, the fractional reduction of noise is a non-monotonous function of protein stability, and can be substantial especially if the inactivated mRNA is stable. We complement the noise study by an extensive mathematical analysis of the joint steady-state distribution of active and inactive mRNA and protein species. We determine its generating function and derive a recursive formula for the protein distribution. The results of the analytical formula are cross-validated by kinetic Monte-Carlo simulation. This is joint work with Pavol Bokes and Abhyudai Singh.


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